A New Method of Thermo-chemotherapy Using a Stent for Patients with Esophageal Cancer |
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Authors: | Seiji Akiyama Shingo Kawasaki Yasuhiro Kodera Kenji Hibi Sawako Kato Katsuki Ito Akimasa Nakao |
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Institution: | (1) Department of Surgery, Ichinomiya Municipal Hospital, 2-2-22 Bunkyo, Ichinomiya, Aichi 491-8558, Japan;(2) Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan |
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Abstract: | Purpose Many patients with advanced esophageal cancer have a stent inserted in the esophagus, but very little else can be done. We
devised a new method of delivering thermotherapy using an implant heating system (IHS) with a metallic stent. To our knowledge,
there are no other reports of thermotherapy using metallic stents. We report our clinical results of treating patients with
this new technique.
Methods A metallic stent was placed in the esophagus and heated for thermotherapy. This was combined with simultaneous chemotherapy
in 13 patients and radio-chemotherapy in 5 patients. Each thermotherapy session consisted of heating the stent to 50°C for
10 min. These 18 patients received a collective 52 sessions of thermotherapy. The tumor was excised after this treatment in
5 of these 18 patients.
Results We evaluated 17 of the 18 patients, after the exclusion of 1 patient who underwent radio-chemotherapy before placement of
the stent. There was 1 complete response (CR) and 12 partial responses (PR), accounting for 76%. The patient with a CR had
no residual cancer cells detected by pathologic examination after surgical resection. Thermotherapy proved effective in 8
(89%) of 9 patients who received this treatment at least three times. It was effective in all (100%) patients who underwent
concomitant radio-chemotherapy.
Conclusions Our results show that thermotherapy using a stent can improve the effectiveness of combination therapy, suppress local tumor
growth, and enhance quality of life over a long period. |
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Keywords: | Thermotherapy Metallic stent Esophageal cancer Chemotherapy Radiotherapy |
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