压力和容量通气模式对肥胖患者腹腔镜手术中呼吸功能的影响

目的 观察肥胖患者行妇科腹腔镜手术时,两种不同的机械通气模式对患者血流动力学、呼吸力学、动脉氧合的影响. 方法 选择40例行妇科腹腔镜手术的肥胖患者,按数字表法随机分为压力控制通气组(pressure-controlled ventilation,PCV)和容量控制通气组(volume-controlled yentilation,VCV),每组20例.两组患者均实施全凭静脉麻醉方案,分别采用不同的通气模式,维持呼气末二氧化碳分压(end-tial carbon dioxide partial pressure,PETCO2)在35 mm Hg～45 mm Hg(1 mm Hg=0.133kPa)之间.分别于麻醉前5 min(T0)、气腹开始前5 min(T1)、气腹后30min(T2)、气腹解除后5 min(T3)、拔除气管导管时(T4),采集动脉血行血气分析,监测和计算血流动力学指标、血气分析指标、呼吸力学指标. 结果 ①在T1、T2、T3 PCV组的PaO2、氧合指数(oxygenation index,OI)(分别为460±78、453±83、463±95)均高于VCV组(P<0.05);PCV组的肺泡动脉血氧分压差(A-aDO2)(分别为74±25、80±30、82±26)、呼吸指数(respiratory index,RI)(分别为0.32±0.08、0.33±0.10、0.34±0.13)明显低于VCV组(P<0.05).②与T0比较,两组在T2、T3、T4 PaCO2明显升高、pH值明显下降(P<0.05);与VCV组比较,PCV组在各时点差异无统计学意义.③与VCV组比较,PCV组在T2气道峰压Ppeak(27.8±1.6)较低(P<0.05). 结论 PCV在肥胖患者的妇科腹腔镜手术麻醉中改善通气与血流比例,促进气体交换.

The effects of ventilation modes of pressure and volume on respiratory function of obese patients undergoing gynecologic laparoscopic surgery

Objective To investigate the effects of pressure -controlled ventilation (PCV) and volume -controlled ventilation (VCV) on obese patients undergoing gynecologic laparoscopic surgery by evaluating hemodynamics and respiratory parameters, and arterial oxygenation. Methods Forty obese patients undergoing gynecological laparoscopic surgery were randomly divided into PCV and VCV group (n=20). Patients were all implemented into the program of total intravenous anesthesia, and ventilated with different modes.End-tidal carbon dioxide partial pressure (PETCO2) was maintained between(35-45 ) mm Hg. Arterial blood was collected respectively to analyze blood gas at 5 min before anesthesia (T0), 5 min before the start of pneumoperitoneum (T1),30 min after the start of pneumoperitoneum(T2), 5 min after the end of pneumoperitoneum(T3) and at extubation(T4). Meanwhile, parameters of hemodynamics and respiratory mechanics were monitored and calculated. Results 1 、At T1,T2 and T3, PaO2 and OI (460±78,453±83,463±95)were significantly higher in PCV group (P<0.05), A-aDO2(74±25,80±30,82±26) and RI (0.32±0.08,0.33±0. 10,0.34±0.13 ) was significantly lower (P<0.05) in PCV group. 2. Compared with T0, PaCO2 at T2,T3,T4 in both groups increased significantly and PH decreased significantly (P<0.05); Compared with VCV group, PCV group had no significant difference at each time point. 3. Compared with VCV group, Ppeak(27.8±1.6)in PCV group at T2 was significantly lower(P<0.05). Conclusion The ventilation/perfusion ratio was improved and gas exchange was promoted in obese patients undergoing gynecologic laparoscopic surgery with PCV model.