高血压患者脉搏波传导速度与血压负荷关系的研究

目的:探讨高血压患者臂踝脉搏波传导速度(BAPOWV)与血压负荷的关系。方法:入选原发性高血压患者348例,进行24 h动态血压监测和BAPWV测定,根据BAPWV的值,将其分为2组:BAPWV正常组(BAPWV<1400cm/s)121例,BAPWV升高组(BAPWV≥1400 cm/s)227例。比较2组患者年龄、性别构成比、血糖、血脂、血肌酐、血尿酸、血压及血压负荷。结果:单因素分析显示,BAPWV升高组患者的年龄、三酰甘油、胆固醇、低密度脂蛋白、血压及血压负荷均显著高于BAPWV正常组(P<0.05)。Logistic回归分析表明年龄、夜间收缩压负荷及夜间舒张压负荷是影响BAPWV的独立因素(P<0.05)。结论:高血压患者夜间收缩压负荷和舒张压负荷是影响BAPWV的独立因素。

Study on the relationship between brachial-ankle pulse wave velocity and blood pressure load in hypertensive patients

Objective:To explore the relationship between brachial-ankle pulse wave velocity and blood pressure load in hypertensive patients.Methods:348 patients were enrolled in this study.Ambulatory blood pressure(ABP) and brachial-ankle pulse wave velocity(BAPWV) were measured.According to the value of BAPWV,all patients were divided into two groups: BAPWV normal group(bapwv<1400 cm/s,n=121) and BAPWV elevated group(bapwv≥1400 cm/s,n=227).The patients’ age,gender ratio,fasting blood glucose(FBG),triglyceride(TG),cholesterol(CHO),low density lipoprotein cholesterol(LDL),high density lipoprotein cholesterol(HDL),creatinine(Cr),uric acid(UA),blood pressure level and blood pressure load were measured.Results:Univariate analysies revealed that age,TG,CHO,LDL,blood pressure and blood pressure load in BAPWV elevated group were significantly higher than those in BAPWV normal group(P<0.05).Logistic multivariate regression analysis indicated that age,nighttime systolic blood pressure load and nighttime diastolic blood pressure load were independent influencing factors of BAPWV.Conclusion:nighttime systolic blood pressure load and nighttime diastolic blood pressure load of hypertensive patients were independent influencing factors of BAPWV.