| 毛冬青缓释胶囊的制备 |
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| 引用本文： | 方芳,张应辉,袁海龙,李仙义,曹琳. 毛冬青缓释胶囊的制备[J]. 解放军药学学报, 2004, 20(6): 470-472 |
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| 作者姓名： | 方芳 张应辉 袁海龙 李仙义 曹琳 |
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| 作者单位： | 中国人民解放军第302医院,药学部,北京,100039;中国人民解放军第181医院,药剂科,广西,桂林,541002;中国人民解放军总后勤部卫生部药品仪器检验所,北京,100071;成都中医药大学,药学院,四川,成都,610075 |
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| 摘 要： | 目的 制备膜控释毛冬青缓释微丸胶囊并研究其体外释药性能。方法 用乙基纤维素等辅料包衣材料，以PEG1000为致孔剂，经薄膜包衣制备毛冬青缓释微丸胶囊，并以体外释放度试验来评价。结果 实验表明体外释药符合Higuchi方程，Q=18．415t^1/2 29．649(r=0．9874)。结论 毛冬青缓释微丸具有较好的释药性能，为一种较理想的口服缓释剂型，制备工艺可行。
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| 关 键 词： | 毛冬青缓释胶囊 微丸 释放度 |
| 文章编号： | 1008-9926(2004)06-0470-03 |
| 修稿时间： | 2004-04-29 |
Preparation of Maodongqing Sustained Release Pellet Capules |
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| Abstract: | Aim To prepare Maodongqing sustained release pellet capsules and study the dissolution rate.Methods The capsules were prepared by the selection of coating material with EC as matrix and PEG1000 as hollow agent,and judged by the release behavior.Results The results showed that the release behavior of the pellet capsules followed Higuchi quation Q=18.415t 1/2 +29.649(r=0.987 4).Conclusion The capsules had good sustained release effect and the process of the preparation was feasible. |
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| Keywords: | Maodongqing Sustained Release capsules pellet Dissolution rate |
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