| 脱落细胞形态计量及DNA含量测定对膀胱癌的诊断意义 |
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| 引用本文： | 郭萍 石勇刚. 脱落细胞形态计量及DNA含量测定对膀胱癌的诊断意义[J]. 昆明医学院学报, 1997, 18(3): 56-59 |
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| 作者姓名： | 郭萍 石勇刚 |
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| 作者单位： | 昆明医学院病理教研室，昆明医学院第一附属医院泌尿外科，云南大学图象分析室 |
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| 摘 要： | 采用图象细胞分析技术（ＩＣＭ）对８例膀胱冲洗液脱落细胞及６例正常对照进行形态计量和ＤＮＡ含量分析研究．结果显示：正常对照ＤＮＡ主峰位于２Ｎ范围，ＤＮＡ含量≥５Ｎ细胞为０．６７％，肿瘤脱落细胞ＤＮＡ主峰右移超过４Ｎ范围，ＤＮＡ含量≥５Ｎ细胞为４３．０％．对膀胱冲洗液脱落细胞的９项几何学参数进行检测，均表明良恶性间有显著差异，核／细胞面积比（ＡＲＮＣ）和细胞圆度（ＳＰＣ）两项参数具有临床诊断价值及代表性．
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| 关 键 词： | 尿脱落细胞，形态计量，DNA含量 |
Significance of Morphometry and DNA Cytometry of Shedding Cells in Diagnosing Bladder Cancers |
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| Guo Ping ) Shi Yonggang ) Huang Run ) Ou Yangming ) Zhang Zhongji ) Zhang Huaxian ). Significance of Morphometry and DNA Cytometry of Shedding Cells in Diagnosing Bladder Cancers[J]. Journal of Kunming Medical College, 1997, 18(3): 56-59 |
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| Authors: | Guo Ping ) Shi Yonggang ) Huang Run ) Ou Yangming ) Zhang Zhongji ) Zhang Huaxian ) |
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| Affiliation: | Guo Ping 1) Shi Yonggang 2) Huang Run 1) Ou Yangming 3) Zhang Zhongji 1) Zhang Huaxian 1) |
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| Abstract: | With the image cytometry (ICM), morphometry and DNA contents were analytically studied on the shedding cells of bladder rinsing solution from 8 cancer suspected persons and 7 normal subjects. The results showed that in the normal cells, DNA main peak was at 2N and the cells with DNA content >5N were 0 67% while in the cancer cells, DNA main peak shifted to the right past 4N; and the cells with DNA content >5N were 43 0%. The detection of the shedding cells revealed a marked difference between the benignant and magnignant. Two parameters, ARNC and SPC, both symbolize the value in clinical diagnosis. |
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| Keywords: | Shedding cells in urine Morphometry DNA content |
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