Diabetes and renal tubular cell apoptosis |
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Authors: | Samy L Habib |
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Affiliation: | Samy L Habib, South Texas Veterans Health Care System, Departments of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, United States |
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Abstract: | Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by which high glucose induces apoptosis is not fully understood. Apoptosis of tubular epithelial cells is a major feature of diabetic kidney disease, and hyperglycemia triggers the generation of free radicals and oxidant stress in tubular cells. Hyperglycemia and high glucose in vitro also lead to apoptosis, a form of programmed cell death. High glucose similar to those seen with hyperglycemia in people with diabetes mellitus, lead to accelerated apoptosis, a form of programmed cell death characterized by cell shrinkage, chromatin condensation and DNA fragmentation, in variety of cell types, including renal proximal tubular epithelial cells. |
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Keywords: | Tubular cells Renal Apoptosis Diabetes |
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| 点击此处可从《World journal of diabetes》浏览原始摘要信息 |
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