Pharmacokinetics in obese patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Pharmacokinetics in obese patients

Authors:	De Baerdemaeker, Luc EC Mortier, Eric P Struys, Michel MRF

Affiliation:	Department of Anaesthesia, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium Eric P Mortier, MD DSc, Professor and Chair of Anaesthesia Department of Anaesthesia, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium Michel MRF Struys, MD PhD, Professor in Anaesthesia and Co-ordinator of Research Department of Anaesthesia, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium Tel: +32 9240 3281, Fax: +32 9240 4987, E-mail: luc.debaerdemaeker{at}ugent.be (for correspondence)

Abstract:	One of the many problems in providing anaesthesia for morbidlyobese patients is the influence of obesity on pharmacokineticsand pharmacodynamics. Drug administration in obese patientsis difficult because recommended doses are based on pharmacokineticdata obtained from individuals with normal weights; therefore,mistakes in the determination of the appropriate dose are oftenmade. Because of comorbidity in these patients, the functionof organs involved in drug elimination (e.g. kidney, liver)can be affected making pharmacokinetics more difficult and complex.

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