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ALK protein expression in pulmonary adenocarcinoma of Tunisian patients |
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| Authors: | Amira Toumi Arfaoui Ahlem Blel Raoudha Aloui Ghaya Fatnassi Jihane Ben Ammar Nadia Znaidi |
| Institution: | 1. Department of Pathology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia;2. Department of Pneumology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia |
| Abstract: | Background. It is now necessary to determine ALK status in order to use targeted therapy. Aim: herein, we assess immunohistochemical profile of ALK protein in a series of Tunisian patients with pulmonary adenocarcinoma. Materials and Methods. ALK protein expression was studied applying the D5F3 antibody with a fully automated Ventana CDx technique on a series of 19 patients. Results. Positive ALK expression was found in one case (5.2%) corresponding to a papillary adenocarcinoma which showed a strong granular and homogenous cytoplasmic staining. The patient was a 30-years-old woman. Conclusion. The frequency of positive ALK expression based on immunohistochemistry in our series was similar to that reported in the world literature. |
| Keywords: | pulmonary adenocarcinoma ALK expression D5F3 antibody immunohistochemistry ALK rearrangements |