彩色多普勒观察中药坎离煎对慢性心力衰竭患者内皮依赖性血管舒张功能的影响

目的:观察慢性心力衰竭(congestive heart failure,CHF)患者坎离煎治疗前后的内皮依赖性血管舒张功能(endothelium-dependent dilation,EDD)的变化.方法:运用彩色多普勒超声观察中药坎离煎对35例CHF患者治疗前后的桡动脉反应性充血后血流介导的血管舒张幅度(flow-mediated dilation,FMD)、搏动指数(pulsatile index,PI)、阻力指数(resistance index,RI),计算基础血流量(baseline blood flow,BF).结果:治疗后FMD显著增高(治疗前后分别为7.06±2.58,9.26±3.19,P＜0.05),但BF、PI及RI均无明显改善.结论:运用彩色多普勒超声观察坎离煎治疗CHF患者EDD的变化,可为中医药治疗CHF的临床疗效评价提供客观依据.

Observation by color Doppler ultrasound on endothelium-dependent dilation of congestive heart failure treated with Kanli Decoction

OBJECTIVE: To observe the changes of endothelium-dependent dilation (EDD) of patients with congestive heart failure (CHF) before and after Kanli Decoction treatment. METHODS: Thirty-five CHF patients were treated with Kanli Decoction. We used color Doppler ultrasound to monitor the flow-mediated dilation (FMD), pulsatile index (PI), resistance index (RI), baseline blood flow (BF), ejection fraction (EF) before and after the treatment. RESULTS: FMD after treatment (9.26+/-3.19) were obviously higher than that before the treatment (7.06+/-2.58) (P<0.05), but BF, PI and RI were not improved. CONCLUSION: Applying color Doppler ultrasound into observation on EDD of patients suffering from CHF and treated by the Kanli Decoction shows that the CHF could be treated by traditional Chinese medicine.