Selective inhibitory effect of new phosphodiesterase inhibitors on PDE isozymes in guinea pig cardiac muscle |
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| Authors: | Sun Kyeong Lee Kwang Il Kwon Ok Pyo Zee |
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| Affiliation: | 1. Korea Research Institute of Chemical Technology, 302-343, Taejeon, Korea
2. College of Pharmacy, Chung Nam National University, 302-764, Taejeon, Korea
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| Abstract: | Selective inhibition of seven new PDE inhibitors on cyclic nucleotide PDE isozymes was investigated. Three PDE isozymes (PDE I, II and III) of guinea pig left ventricular muscles were used. All tested agents inhibited cyclic AMP hydrolysis by PDE III in a concentration-dependent manner. Some agents represented more potent and selective inhibitory effect on PDE III than that of imazodan. |
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| Keywords: | Inotropic agents congestive heart failure selective PDE inhibitor |
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