| 对大鼠脊髓损伤应用红花注射液的保护作用 |
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| 引用本文： | 陈剑峰,田小武,唐天驷. 对大鼠脊髓损伤应用红花注射液的保护作用[J]. 中国矫形外科杂志, 2011, 19(22): 1913-1917 |
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| 作者姓名： | 陈剑峰 田小武 唐天驷 |
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| 作者单位： | 苏州大学附属第一医院骨科;南京中医药大学无锡附属医院脊柱脊髓科; |
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| 基金项目： | 无锡市社会发展指导性计划项目(编号:CLZ00625) |
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| 摘 要： | [目的]采用重物下降打击法,制备相当于中度大鼠脊髓损伤(spinal cord injury,SCI)的模型,探讨红花注射液对SCI的保护效果。[方法]将72只SD大鼠随机分为假手术组(A组)、脊髓打击损伤组(B组)、甲基强的松龙组(methylprednisolone sodium succinate,MPSS)(C组)、红花溶液组(D组),每组18只。B、C、D组根据改良的重物撞击装置制备脊髓急性打击损伤动物模型,C、D组在脊髓打击损伤后即刻分别腹腔注射MPSS 30 mg/kg和红花溶液100 mg/kg,观察并检测4组大鼠SCI后1、24、48 h 3个不同时间点后肢运动功能评分变化以及脊髓组织病理学、组织含水量、乳酸(lactic acid,LD)含量、乳酸脱氢酶(lactic dehydrogenase,LDH)活性、超氧化物歧化酶(superoxide dismutase,SOD)活性、丙二醛(malondialdehyde,MDA)含量的改变。[结果]术后A组大鼠功能完全恢复;C组或D组与B组相比,大鼠后肢运动功能24、48 h 2个时间点均有所改善,但24 h时已出现明显差异(P<0.05)...
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| 关 键 词： | 红花注射液 脊髓损伤 大鼠 |
Protective effect of safflower injection on spinal cord injury in rats |
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| CHEN Jian-feng,TIAN Xiao-wu,TANG Tian-si. Protective effect of safflower injection on spinal cord injury in rats[J]. Orthopedic Journal of China, 2011, 19(22): 1913-1917 |
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| Authors: | CHEN Jian-feng TIAN Xiao-wu TANG Tian-si |
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| Affiliation: | CHEN Jian-feng,TIAN Xiao-wu,TANG Tian-si.Department of Orthopaedics,the First Hospital Affilated to Suzhou University,Suzhou 215006,China |
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| Abstract: | [Objective] To study the protective effects of safflower on the experimental spinal cord injury(SCI) model with weight-dropping method in adult rats.[Method]Seventy-two SD rats were randomly divided into 4 groups:sham-operation group(group A),spinal cord injury group(group B),methylprednisolone sodium succinate(MPSS) group(group C),and safflower group(group D).Animal models of spinal cord injury were induced with weight-dropping method.In the C and D groups,MPSS of 30 mg/kg and safflower of 100 mg/kg was re... |
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| Keywords: | safflower injction spinal cord injury rats |
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