中西药预防人工髋关节术后深静脉血栓形成的临床对照观察

[目的]探讨中药血栓通预防全髋关节置换术后并发深静脉血栓形成的效果及用药安全性.[方法]选择行全髋关节置换术的符合研究标准的112例患者,随机分为中药预防组58例,西药预防组54例.两组在采用相同的基本预防措施和机械预防措施的基础上,分别采用中药血栓通注射液和西药低分子肝素钠针剂对手术后可能发生的深静脉血栓(DVT)进行预防.比较两组术后DVT发生率,术前及术后7d和14d后活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、国际标准化比值(INR)、血小板计数(PLT)等凝血指标及术中出血量、术后伤口引流量等安全性指标变化的差异.[结果]中药预防组发生DVT16例,DVT发生率27.58％；西药预防组发生DVT13例,DVT发生率24.07％；经统计学检验,差异无统计学意义.两组间术前APTT比较,差异无统计学意义(P＞0.05)；两组间术后7、14d的APTT比较,差异均有统计学意义(P＜0.01).两组间PT术前、术后7、14d比较,差异无统计学意义(P＞0.05).两组间INR术前、术后7、14d比较,差异均无统计学意义(P＞0.05).两组间PLT术前及术后7、14d比较,差异均无统计学意义(P＞0.05).两组术前术后凝血指标的实际数值均在正常范围之内.两组间术中出血量、术后伤口引流量等安全性指标比较,无显著性差异.[结论]单独应用中药血栓通防治髋关节置换术后DVT可获得与西药低分子肝素钠近似的疗效和安全性.

A comparative study of Chinese herbal medicine and western medicine for prophylaxis against deep venous thrombosis

[Objective]To investigate the effect and safety of Xueshuantong(XST) injection(a Chinese herbal medicine) for prophylaxis against deep venous thrombosis(DVT) after total hip arthroplasty(THA),and compare it with low-molecular-weight heparin(LMWH). [Methods]One hundred and twelve eligible patients with THA were randomly divided into two groups,Group A(n=58) and Group B(n=54).The same elementary prophylactic measures were given to all the patients.Besides,Group A was given XST injection while Group B was give...