ATP and control of intracellular growth of mycobacteria by T cells |
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| Authors: | Canaday David H Beigi Reza Silver Richard F Harding Clifford V Boom W Henry Dubyak George R |
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| Affiliation: | Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44109, USA. dxc44@cwru.edu |
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| Abstract: | Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes. |
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