血栓调节蛋白基因多态性与冠心病相关性的Meta分析

目的评价血栓调节蛋白(TM)基因G-33A和C1418T多态性与冠心病(CHD)的相关性。方法检索Cochrance图书馆、PubMed数据库、中国生物医学文献数据库(CBM)、万方数据库和中国学术期刊全文数据库(CNKI),检索日期为1987年1月1日至2013年4月30日,收集血栓调节蛋白基因多态性与冠心病相关性的病例对照研究和队列研究,按照纳入和排除标准选择提取数据资料并评价,采用RevMan5.2.3软件进行Meta分析。结果共纳入14篇文献(病例组3039例,对照组5480例)。Meta分析显示,亚洲人TM基因G-33A多态性和CHD之间存在相关性(G vs.A,P=0.002;GG vs.GA,P=0.002;GG vs.GA+AA,P=0.0002),而C1418T多态性和CHD之间不存在相关性(P0.05)。结论亚洲人TM基因G-33A多态性与CHD之间存在相关性,而C1418T多态性和CHD之间不存在相关性。

A Meta-analysis on correlation between genetic polymorphism of thrombomodulin and coronary heart disease

Objective To review the correlation between genetic polymorphism of thrombomodulin （TM） and coronary heart disease （CHD）. Methods The databases of Cochrance Library, PubMed, CBM, WanFang Database and CNKI were retrieved from Jan. 1, 1987 to Apr. 30, 2013 for collecting case-control studies and cohort studies on the correlation between genetic polymorphism of TM and CHD. The data was extracted according to the inclusion and exclusion criteria and reviewed, and then given a Meta-analysis by using RevMan5.2.3 software. Results There were totally 14 studies included involving 3039 cases in case group and 5480 in control group. The Meta-analysis showed that there was correlation between genetic polymorphism of TM G-33A and CHD （G vs. A, P=0.002;GG vs. GA, P=0.002;GG vs. GA＋AA, P=0.0002） in Asian population, while there was no correlation between genetic polymorphism of C1418T and CHD （P〈0.05）. Conclusion The genetic polymorphism of TM G-33A is correlated and C1418T is not to CHD.