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| 中性粒细胞对洗涤血小板聚集功能的影响 | |
| 引用本文： | 沈志强,吴蓝鸥,段理,陈植和,雷伟亚,刘吉开. 中性粒细胞对洗涤血小板聚集功能的影响[J]. 中国病理生理杂志, 2002, 18(7): 801-803 |
| 作者姓名： | 沈志强 吴蓝鸥 段理 陈植和 雷伟亚 刘吉开 |
| 作者单位： | 1. 昆明医学院, 云南省天然药物药理重点实验室, 云南 昆明 650031; 2. 昆明医学院, 第一附属医院放射科, 云南 昆明 650031; 3. 中国科学院昆明植物研究所开放实验室, 云南 昆明 650204 |
| 基金项目： | 云南省自然科学基金资助项目 (No .98C0 6 6M) |
| 摘 要： | 目的:观察非激活或激活的中性粒细胞(PMN)对洗涤血小板聚集功能的影响。方法:采用Born方法测定血小板聚集功能。结果:非激活的PMN(5×109cells/L)上清液对ADP和花生四烯酸(AA)诱导的血小板聚集具有显著抑制作用,阿司匹林可增强这种抑制作用;肉豆寇佛波醇(fMLP)及血小板活化因子(PAF)激活的PMN悬液或其上清液均能活化血小板聚集,且PMN悬液的诱聚作用比其上清液更强;阿司匹林对fMLP或PAF激活的PMN悬液或其上清液均无明显抑制作用。结论:不同状态(非激活或激活状态)的PMN对正常血小板的反应性表现出完全相反的作用,即非激活的PMN抑制血小板反应性,而激活的PMN则具有促血小板活化聚集作用。 |
| 关 键 词： | 血小板 中性白细胞 血小板聚集 阿司匹林 |
| 文章编号： | 1000-4718(2002)07-0801-03 |
| 收稿时间： | 2001-03-13 |
| 修稿时间： | 2001-03-13 |
Effect of polymorphonuclear leukocytes on washed platelet aggregation |
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| SHEN Zhi-qiang ,WU Lan-ou ,DUAN Li ,CHEN Zhi-he ,LEI Wei-ya ,LIU Ji-kai. Effect of polymorphonuclear leukocytes on washed platelet aggregation[J]. Chinese Journal of Pathophysiology, 2002, 18(7): 801-803 | |
| Authors: | SHEN Zhi-qiang WU Lan-ou DUAN Li CHEN Zhi-he LEI Wei-ya LIU Ji-kai |
| Affiliation: | 1. Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, China; 2. Department of Radiology, the First Affiliated Hospital, Kunming Medical College, Kunming 650031, China; 3. Opening Laboratories, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming 650204, China |
| Abstract: | AIM:To investigate the effect of non-activated or activated polymorphonuclear leukocytes(PMN) on washed platelet aggregation. METHODS:Born's method was used to determine platelet aggregation.RESULTS:non-activated PMN (5×109 cells/L) significantly suppressed washed platelet aggregation induced by ADP or arachidonic acid. Aspirin enhanced this inhibition. N-formyl-methiongl-leucy-phenylalanine (fMLP)-or platelet-activating factor (PAF)-stimulated PMN strongly induced platelet aggregation, and the induction effect of PMN suspension was more active than that of PMN supernatant. Aspirin had no significant inhibitory effect on platelet aggregation induced by fMLP-or PAF-activated PMN. CONCLUSIONS:Different conditions of PMN (activated or non-activated) had the nearly opposite action on normal platelet reactivity. Briefly, non-activated-PMN inhibited platelet reactivity, whereas activated PMN stimulated it. |
| Keywords: | Blood platelets Neutrophils Platelet aggregation Aspirin |
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