皮肤扩张术后的组织退行性变研究

目的探讨扩张术对皮肤的损伤及退行性变作用.方法选择常规间断扩张和持续恒压扩张术各9例,在扩张皮瓣术中切取标本作组织病理学、分子生物学及透射电子显微镜观察.结果扩张可引起毛细血管出血,损伤修复纤维(网状纤维和弹力纤维)增生,微小动脉血栓形成,成纤维细胞凋亡增加,胶原纤维溶解.常规间断扩张后皮肤以退行性变为明显,持续恒压扩张后皮肤急性损伤明显.结论扩张刺激可引起组织急性损伤和退行性变,提示常规扩张时间不能过长,持续扩张不能过快.

Investigation on skin retrograde degeneration after tissue expansion

Objective To study the effects of tissue expansion on tissue damage and retrograde degeneration. Methods 9 cases of conventional intermittent tissue expansion (CITE) and 9 cases of continuous pressure-controlled tissue expansion (CPTE) were chosen for the study. In creating of the expanded flaps, tissue samples were taken for histopathology, molecular biology and transmission electron microscope (TEM) examinations. Results Capillary bleeding, elastic and reticular fiber proliferation, arteriole thrombosis, fibroblast apoptosis and collagenolysis were observed after expansion. Retrograde degeneration was obvious in CITE group and acute lesion was obvious in CPTE group. Conclusion Expansion stimulation induces tissue damage and retrograde degeneration, which indicates that the time for conventional intermittent expansion should be shortened and too fast continuous expansion is harmful.