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A monoclonal antibody to the HLA-A3 alloantigen |
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| Authors: | Dominique Bourel Renée Fauchet Bernard Genetet Genevièvre Merdrignac Daniel Hurez |
| Affiliation: | 1. Centre Régional de Transfusion Sanguine, Rue Pierre Jean Gineste, 35000 Rennes, France;7. Groupe Universitaire de Recherche en Immunologie Fondamentale et Appliquée, Université de Rennes 1, France;71. Service Commun de Cytofluorométrie, Université de Rennes 1, Rennes, France;77. Laboratoire d''Immunologie, C.H.U. Angers, France |
| Abstract: | Monoclonal antibody production recognizing the HLA-A3 antigen is described. The XI-23 antibody reacted with all of the 89 cell suspensions carrying the HLA-A3 antigen (100% cytotoxicity) among a total of 191 suspensions tested. No extra-reactivity or cross-reactivity was observed, particularly with that of HLA-A11. This antibody can thus be considered as a good HLA-typing reagent. |
| Keywords: | major histocompatibility complex monoclonal antibodies lymphocytotoxicity |
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