C3c and C3d fragments of human C3 bind myeloma IgG1 and IgG3 proteins |
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| Authors: | Aarno Hautanen Annikki Sarnesto Jorma Keski-Oja Ilkka Seppälä |
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| Affiliation: | 1. Department of Virology, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland;1. Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland |
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| Abstract: | Eight human myeloma proteins, two of each IgG subclass, were studied for binding to solid-phase C3c and C3d by the ELISA technique. Myeloma IgG1κ, IgG1λ, IgG3κ and IgG3λ proteins bound to C3c and C3d, while two IgG2κ, and two IgG4κ proteins failed to show significant binding affinity. The results suggest that like C1q, the stable binding sites of C3, located on the C3c and C3d parts of the molecule, have affinity for IgG subclasses 1 and 3. |
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