血管内皮生长因子、细胞角蛋白19片段鉴别良恶性胸腔积液的临床价值

目的探讨联合检测血清和胸腔积液中血管内皮生长因子、细胞角蛋白19片段对鉴别结核性与肺癌性胸腔积液的临床价值。方法分别采用双抗体夹心酶联免疫吸附和电化学发光免疫法检测肺癌性和结核性胸腔积液患者血清和胸腔积液中血管内皮生长因子及细胞角蛋白19片段的表达水平。结果肺癌性胸腔积液患者血清和胸腔积液中血管内皮生长因子及细胞角蛋白19片段的表达水平比较有统计学意义（P〈0．01），联合检测可使敏感性提高至92．00％，特异性提高至86．84％。结论联合检测胸腔积液和血清中血管内皮生长因子、细胞角蛋白19片段，对鉴别肺癌性与结核性胸腔积液具有重要的临床价值。

Clinical value of combined detection of vascular endothelial growth factors and cytokeratin 19 fragment in differentiating tuberculous pleural effusion from pleural effusion caused by lung cancer

Objective To evaluate the significance of combined detection of vascular endothelial growth factors (VEGF) and cytokeratin 19 fragment (CYFRA21-1) in serum and pleural effusion in differentiating tuberculous pleural effusion from pulmonary carcinoma caused by lung cancer.Methods Levels of VEGF and CYFRA21-1 in serum and pleural effusion in patients with pulmonary carcinoma and tuberculosis were detected.Sensitivity ratios of VEGF,CYFRA21-1 and combined detection were obtained.Results Levels and positive rate of VEGF and CYFRA21-1 in serum and pleural effusion in patients with pulmonary carcinoma were significantly higher than that in patients with tuberculosis (P<0.01).The sensitivity and specificity of the combined detection of VEGF and CYFRA21-1 in serum and pleural effusion were high compared with those of single index.Conclusion Combined detection of VEGF and CYFRA21-1 in serum and pleural effusion was of great clinical value in differentiating tuberculous pleural effusion from pulmonary carcinoma caused by lung cancer.