红龙夏海汤加减联合西药治疗老年高血压临床观察

目的:观察红龙夏海汤加减联合西药治疗老年高血压患者的临床效果。方法:选择在我中心全科门诊就诊的老年高血压患者120例,随机分为西药组和中西组各60例。两组均给予常规基础治疗,西药组给予西药降血压,中药组在西药组基础上加用红龙夏海汤加减进行治疗,两组治疗均以4周为1个疗程,均治疗3个疗程。观察两组治疗前后血压变化情况(舒张压、收缩压)及24小时动态血压监测指标(24小时舒张压、24小时收缩压);并观察治疗前后两组患者肾素(PRA)及血管紧张素Ⅱ(AngⅡ)变化情况。对两组患者治疗前后中医证候进行积分,积分越高,症状越明显;判断两组治疗后疗效(显效、有效、无效),计算总有效率。结果:治疗后,中西组舒张压、收缩压、24小时舒张压、24小时收缩压,较西药组均明显降低,差异有统计学意义(P<0.05);治疗后,中西组肾素(PRA)及血管紧张素Ⅱ(AngⅡ),较西药组均明显降低,差异有统计学意义(P<0.05);治疗后,中西组中医证候积分(9.33±2.52)分,明显低于西药组(10.69±3.39)分,差异有统计学意义(P<0.05);治疗后,中西组总有效率86.67%,明显高于西药组71.67%,差异有统计学意义(P<0.05)。结论:老年高血压患者使用红龙夏海汤加减联合西药治疗后临床效果较好。

Clinical Observation of Using Modified Honglong Xiahai Decoction Combined with Western Medicine in the Treatment of Elderly Patients with Hypertension

Objective: To study the clinical effect of using Modified Honglong Xiahai Decoction combined with western medicine in the treatment of elderly hypertensive patients. Methods: 120 cases of elderly patients with hypertension treated in our hospital were randomly divided into western medicine group(n=60) and Chinese and western medicine group(n=60). The two groups were given conventional basic treatment,and the western medicine group was given western medicine to lower blood pressure,and Chinese and western medicine group was added with Honglong Xiahai Decoction on the basis of western medicine group. 4 weeks was as a course of treatment,and they were treated for 3 courses. The blood pressure changes(diastolic blood pressure,systolic blood pressure) and the parameters of 24 h ambulatory blood pressure monitoring(24 h diastolic blood pressure,24 h systolic blood pressure) were observed and compared between the two groups before and after treatment,and the changes of plasma renin activity(PRA) and angiotensin Ⅱ(Ang Ⅱ) were observed before and after treatment,and the TCM syndromes were scored before and after treatment(the higher the score was,the more obvious the symptoms were),and the efficacy(markedly effective,effective,ineffective) was judged in the two groups after treatment,and the total effective rate was calculated. Results: After treatment,the diastolic blood pressure,systolic blood pressure,24 h diastolic blood pressure and 24 h systolic blood pressure in Chinese and western medicine group were significantly lower than those in the western medicine group(P<0.05). After treatment,the levels of PRA and AngⅡ in Chinese and western medicine group were significantly lower than those in western medicine group(P<0.05). After treatment,the score of TCM syndromes in Chinese and western medicine group was significantly lower than that in western medicine group (9.33±2.52) points vs(10.69±3.39) points](P<0.05). After treatment,the total effective rate in Chinese and western medicine group was significantly higher than that in western medicine group(86.67% vs 71.67%)(P<0.05). Conclusions: Using Modified Honglong Xiahai Decoction combined with western medicine has good clinical effects in the treatment of elderly patients with hypertension.