八味清肺汤联合阿奇霉素治疗小儿支原体肺炎(痰热闭肺证)的临床疗效及对中医证候积分和血清炎症因子的影响

目的:探讨八味清肺汤联合阿奇霉素治疗对小儿支原体肺炎(痰热闭肺证)的临床疗效、中医证候积分及血清炎症因子的影响。方法:选取我院2015年5月~2017年5月收治的支原体肺炎痰热闭肺证患儿120例,按随机区组设计分为观察组(n=60)和对照组(n=60)。对照组仅给予阿奇霉素治疗,观察组给予八味清肺汤联合阿奇霉素治疗,均治疗2周后比较两组临床疗效、中医证候积分、血清炎症因子水平变化,并比较两组患儿临床症状体征消失时间及不良反应。结果:观察组治疗愈显率显著高于对照组(P<0.05);观察组退热、气喘、咳嗽、肺部啰音消失时间、食欲改善时间及住院时间均显著少于对照组(P<0.001);治疗前两组中医证候积分、血清IL-6、IL-8、IFN-γ、TNF-α水平比较差别均无统计学意义(P>0.05),治疗后观察组中医证候积分及炎症因子水平改善显著优于对照组(P<0.05),且两组不良反应发生率比较无统计学意义(P>0.05)。结论:八味清肺汤联合阿奇霉素治疗小儿支原体肺炎痰热闭肺证疗效显著优于单用阿奇霉素,能显著改善中医证候积分及炎症因子水平,且不增加明显副反应。

Effects of Bawei Qingfei decoction combined with azithromycin on clinical efficacy,TCM syndromes scores and serum inflammatory factors in children with mycoplasma pneumonia (accumulation of phlegm-heat syndrome)

Objective To explore the effects of Bawei Qingfei decoction combined with azithromycin on clinical efficacy,TCM syndromes scores and serum inflammatory factors in children with mycoplasma pneumonia(accumulation of phlegm-heat syndrome).Methods A total of 120 children patients with mycoplasma pneumonia(accumulation of phlegm-heat syndrome)admitted to our hospital from May 2015 to May 2017 were selected and divided into observation group(n=60)and control group(n=60)according to the randomized block design.Control group was only given azithromycin,and observation group was given Bawei Qingfei decoction combined with azithromycin.After 2 weeks of treatment,the clinical efficacy,TCM syndromes scores and serum inflammatory factor levels were compared between the two groups,and the disappearance times of clinical symptoms and signs,and adverse reactions were compared between the two group.Results The good improvement rate of treatment in observation group was significantly higher than that in control group(P<0.05).The disappearance times of fever,asthma,cough and lung rales,the improvement time of appetite and hospital stay in observation group were significantly less than those in control group(P<0.001).There were no significant differences in the TCM syndromes scores and levels of serum IL-6,IL-8,IFN-γand TNF-αbetween the two groups before treatment(P>0.05).After treatment,the TCM syndromes scores and inflammatory factors levels in observation group were significantly better than those in control group(P<0.05),and there was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusions Bawei Qingfei decoction combined with azithromycin has significantly better efficacy than azithromycin in the treatment of children with mycoplasma pneumonia(accumulation of phlegm-heat syndrome).and it can significantly improve TCM syndromes scores and inflammatory factors level without increasing obvious side effects.