环氧合酶-2在子宫内膜癌中表达及临床意义的研究进展

环氧合酶-2（cox-2）是前列腺素合成过程中的重要限速酶，研究表明其过度表达与肿瘤的发生发展密切相关，可能通过促进细胞增殖，抑制细胞凋亡，促进血管形成及抑制机体免疫等机制促进肿瘤的形成。近年来研究发现COX-2不仅在子宫内膜癌组织中高表达，并与子宫内膜癌的一些临床病理特征和预后之间存在联系，提示其可能成为判断肿瘤恶性程度、转移能力及预后的新的生物学指标。现将COX-2在子宫内膜癌中的表达及其临床意义的研究进展作一综述。

Expression of cyclooxygenase-2 and its clinicopathologic and prognostic significance in endometrial cancer

Cyclooxygenase-2(COX-2)is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers.Data indicate that COX-2 is involved in the regulation of apoptosis,angiogenesis,and immune response.The biological function of COX-2 appears to be associated with tumorigenesis.Recently, multiple studies have shown that COX-2 plays a critical role not only in maintenance of the endometrium during the menstrual cycle,but also in the progression of endometrial cancer.This review outlines the status of COX-2 expression and its association with clinicopathologic features and clinical outcome in endometrial cancer.