非胰岛素依赖型糖尿病患者尿白蛋白与血管病变的关系

按２４ｈ尿白蛋白排泄量（ＵＡＥ）将５８例非胰岛素依赖型糖尿病患者分为尿白蛋白正常组（Ⅰ组）和微量尿白蛋白组（Ⅱ组），比较两组血脂、血压、冠心病及视网膜微血管病变的差异。结果示：Ⅱ组载脂蛋白Ａ１（ＡｐｏＡ１），载脂蛋白Ａ１与载脂蛋白Ｂ１００的比值（ＡｐｏＡ２／ＡｐｏＢ１００）较Ⅰ组降低（Ｐ＜０．０５），冠心病、视网膜微血管病变的发生率明显增高（Ｐ＜０．０５）。相关性分析示ＡｐｏＡ１，ＡｐｏＡ１／ＡｐｏＢ１００值和高密度脂蛋白（ＨＤＬ）与２４ｈＵＡＥ呈负相关；收缩血压与２４ｈＵＡＥ呈正相关。提示微量白蛋白尿与ＮＩＤＤＭ脂质代谢紊乱及合并血管病变有关。

RELATIONSHIP BETWEEN URINARY ALBUMIN EXCRETION AND BLOOD VESSEL LESION IN NON INSULIN DEPENDENT DIABETICS

To search the relationships between urinary albumin excretion and blood vessel lesion in non insulin dependent diabetics, we compared the differences of blood lipid, blood pressure, coronary heart disease and retina disease between 58 patients. The group with microalbuminuria had significantly lower concentration of apolipoprotein A, and apolipoprotein A 1/apolipoprotein B 100 than that of the group with normal albuminuria, but there was no significant change in concentrations of trigly cerides, total cholesterol, high density lipoprotein, and apolipoprotein B 100 . Coronary heart disease and retina disease were significantly increased in group with microalbuminuria. There was negative correlation with apolipoprotein A 1 and value of apolipoprotein A 1/apolipoprotein B 100 , but positive correlation with systolic blood pressure by linear regression analysis for urinary albumin excretion.