| 荧光素-卟啉的合成及其清除活性氧自由基性质 |
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| 引用本文： | 陆家政,郭海伟,黄锦汪,蒋京,曾宪栋,臧林泉. 荧光素-卟啉的合成及其清除活性氧自由基性质[J]. 右江民族医学院学报, 2010, 32(6). DOI: 10.3969/j.issn.1001-5817.2010.06.002 |
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| 作者姓名： | 陆家政 郭海伟 黄锦汪 蒋京 曾宪栋 臧林泉 |
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| 基金项目： | 国家教育部科学技术研究重点项目,广东药学院启动基金项目 |
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| 摘 要： | 目的合成一种与醚键相连含自由羧基的荧光素-卟啉二元化合物并研究其体外清除活性氧自由基。方法以元素分析、UV-Vis、IR、1H-NMR和ESI-MS对目标物质进行表征;用分光光度法测定荧光素-卟啉化合物体外清除活性氧自由基的性质。结果合成产物为目标荧光素-卟啉二元化合物,该化合物可有效清除活性氧自由基。结论带活性官能团的荧光素-卟啉化合物可能是一种良好的自由基清除剂。
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| 关 键 词： | 荧光素-卟啉 活性氧 自由基清除剂 |
Synthesis of a fluorescein-porphyrin hybrid and its scavenging effects on active oxygen free radicals |
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| LU Jia-zheng,GUO Hai-wei,HUANG Jin-wang,JIANG Jing,ZENG Xian-dong,ZANG Lin-quan. Synthesis of a fluorescein-porphyrin hybrid and its scavenging effects on active oxygen free radicals[J]. Journal of Youjiang Medical College For Nationalities, 2010, 32(6). DOI: 10.3969/j.issn.1001-5817.2010.06.002 |
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| Authors: | LU Jia-zheng GUO Hai-wei HUANG Jin-wang JIANG Jing ZENG Xian-dong ZANG Lin-quan |
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| Abstract: | Objective To Synthesis of a porphrin-fluorescein hybrid,and study its scavenging effects on active oxygen species in vitro. Methods Porphrin-fluorescein Hybrid was characterized by UV/Vis,IR,1H-NMR,ESI-MS and elemental analysis.Its scavenging effects on active oxygen species was investigated by the means of spectrophotometry.Results A fluorescein-porphyrin hybrid has been synthesized and characterized.Porphyrin fluorescein hybrid could scavenge active oxygen free radical efficiently.Conclusion The porphyrin fluorescein hybrid is a good free radical scavenger agent in vitro. |
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| Keywords: | fluorescein-porphyrin hybrid active oxygen free radical scavengers |
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