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Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia |
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| Authors: | Silva Glauce N Martins Fabíola R Matheus Maria Eline Leitão Suzana G Fernandes Patricia D |
| Institution: | aDepartamento de Farmacologia Básica e Clínica/ICB, Centro de Ciências da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitária, Caixa Postal 68 016, 21944-970 Rio de Janeiro, Brazil bDepartamento de Produtos Naturais e Alimentos, Faculdade de Farmácia, UFRJ, CCS, Bloco A, 2o andar, Cidade Universitária, 21941-590 Rio de Janeiro, Brazil |
| Abstract: | The anti-inflammatory activity of Lantana trifolia (Verbenaceae) was determined by carrageenan, serotonin and histamine-induced rat paw edema and the analgesic activity of this plant was studied by acetic acid-induced writhings and tail flick tests in mice. Lantana trifolia extracts (at 30 mg/kg) inhibited carrageenan and histamine-induced rat paw edema. Although the extracts did not produce any effect on acetic acid-induced writhings, they all develop a significant increase on tail flick antinociceptive index (doses varying between 1 and 30 mg/kg), indicating a spinal antinociceptive effect. These results provide support for the use of Lantana trifolia in relieving inflammatory pain. |
| Keywords: | Lantana trifolia Verbenaceae Antinociceptive activity Anti-inflammatory activity Medicinal plant |
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