| 黎药胆木不同提取部位急性毒性实验研究 |
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| 引用本文： | 杨卫丽,赖伟勇,张俊清,刘明生.黎药胆木不同提取部位急性毒性实验研究[J].时珍国医国药,2010,21(3). |
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| 作者姓名： | 杨卫丽 赖伟勇 张俊清 刘明生 |
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| 作者单位： | 海南医学院药学系,海南省热带药用植物研究开发重点实验室,海南,海口,571101 |
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| 基金项目： | 海南省自然科学基金，海南省海口市重点科技计划项目 |
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| 摘 要： | 目的 观察胆木不同提取部位的急性毒性.方法 以最大浓度及最大给药体积的药液灌胃给药, 3次/d.连续观察7 d,记录小鼠毒副反应情况.结果 观察7 d后,全部动物健存,小鼠体重平均增长28.14%和21.46%,均未见任何毒性反应.胆木水提物最大给药量为400 g/kg体重,相当于成人日用量的200倍;胆木总生物碱给药量为24 g/kg.结论 胆木不同提取部位毒性均较小.
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| 关 键 词： | 胆木 急性毒性 总生物碱 |
Study on the Acute Toxicity of Different Extractions of Nauclea offcinalis |
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| YANG Wei-li,LAI Wei-yong,ZHANG Jun-qing,LIU Ming-sheng.Study on the Acute Toxicity of Different Extractions of Nauclea offcinalis[J].Lishizhen Medicine and Materia Medica Research,2010,21(3). |
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| Authors: | YANG Wei-li LAI Wei-yong ZHANG Jun-qing LIU Ming-sheng |
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| Institution: | YANG Wei-li,LAI Wei-yong,ZHANG Jun-qing,LIU Ming-sheng(Hainan Medical College,Hainan Provincial Key Laboratory of R&D of Tropical Herbs,Haikou,Hainan 571101,China) |
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| Abstract: | Objective To study the acute toxicity of different extracts of Nauclea offcinalis(DEONO).Methods The maximum administration dosage of DEONO was determined by ig administration in mice,and three times a day.Its acute toxic reactions were observed for 7 days.Results All mice were survive,and no toxic reaction was shown during the observed period.The average rate of increasing weight of water extract and total alkloids were 28.1% and 21.47%,respectively.The maximum administration dosage(400 g/kg) of water extr... |
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| Keywords: | Nauclea offcinalis Acute toxicity Total alkloids |
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