甲状腺病变的液基细胞学诊断病理分析

 目的 探讨液基细胞学方法处理标本在甲状腺病变针吸细胞学诊断的应用价值。 方法 采用利普液基细胞学（liquid-PRER，LPT）和传统手工制片方式对229例甲状腺病变患者细针穿刺细胞学诊断结果，并对两种制片方法进行比较。 结果 应用LPT技术保存标本和制片，诊断性细胞数量明显增多，背景清洁，分布均匀，玻片中较少见到甲状腺胶质，而核细节更容易观察。LPT制片甲状腺癌的阳性诊断率6.55%(15/229),传统涂片3.93%（9/229）。 结论 LPT技术用于甲状腺细针穿刺能明显提高标本质量和甲状腺癌阳性诊断率，为诊断甲状腺病变提供了一种可靠而有前景的诊断方法。

Pathological analysis of liquid-based cytological diagnosis in fine needle aspiration of thyroid lesion

Objective To evaluate the liquid-based cytology in the diagnosis of thyroid diseases.Methods Two hundred cases of thyroid lesion in outpatient and inpatient departments underwent liquid-based cytological examinations to compare the quality and diagnosis of traditional manual smear preparation.Results The preserved specimens and smears made with liquid-PREP showed an increased number of valuable cells,a cleaner background,uniform distribution,less thyroid colloid in the smear and clear nuclei.The positive rate of thyroid cancer was 6.55%(15/229) in liquid-PREP and 3.93%(9/229) in traditional manual smear preparation.Conclusions Liquid-PREP improves the smear quality and positive rate of cancer in thyroid fine needle aspiration cytology and can serve as a promising diagnostic method for thyroid lesion.