笑气清醒镇静对肠镜检查的有效性和安全性评价

 目的 研究笑气（N 2O）清醒镇静在肠镜检查中的安全性和有效性。 方法 将 2011-04至2011-12在我院行笑气清醒 镇静肠镜检查的330例患者作为A组，同期常规肠镜检查300例患者作为B组，对其HR、SpO 2、反应情况及镇静效果等进行研 究分析。 结果 A组术中不适反应明显低于B组。A组中，术中HR低于术前［（74.90±13.65）次/min vs （79.16±14.67）次/min， P ＜0.05］，但术中HR在正常安全范围内；术中SpO 2高于与术前［99.64±1.04）% vs （99.14±1.35）%， P ＜0.05］。B组中，术中HR高于术前［（89.80±13.52） vs (79.77±13.35)， P ＜0.05］ ；术中SpO 2稍低于与术前［（99.42± 1.07 ）% vs (99.53±1.12)%］，但差异无统计学意义。 结论 笑气清醒镇静肠镜检查提高了肠镜检查的舒适度，安全、可行。

Safety and efficacy of nitrous oxide for colonoscopy

Objective To study the safety and effectiveness of nitrous oxide(≤70%) for colonoscopy.Methods A total of 630 patients who underwent colonoscopy from April 2011 to December 2011 were divided into group A(nitrous oxide-colonoscopy group,n=330) and group B(conventional colonoscopy group,n=300).Their heart rate(HR),oxygen saturation and sedative effects were compared.Results The perioperative reaction in group A was obviously lower than in group B.In group A,the perioperative HR was obviously lower than the preoperative HR (74.90±13.65)vs(79.16±14.67),P<0.05] and the perioperative SpO2 was significantly higher than the preoperative SpO2 (99.64±1.04)% vs(99.14±1.35)%,P<0.05].In group B,the perioperative HR was significantly higher than the preoperative HR(89.80±13.52)vs(79.77±13.35),P<0.05] and the perioperative SpO2 was slightly higher than the preoperative SpO2 (99.64±1.04)% vs(99.14±1.35)%,P<0.05],but the difference was not statistically significant.Conclusions Nitrous oxide for colonoscopy is comfortable,safe and feasible.