嗅觉定量检测与帕金森病早期诊断的相关性研究

目的探讨应用嗅觉定量测量方法在临床实际帕金森病早期是否存在诊断意义。方法采用嗅觉定量检测嗅阈,比较30例帕金森病患者(PD组)和25名阿尔茨海默病(AD组)以及30例正常人,分析各组组间年龄、性别、发病时间以及PD组内UPDRS评分、H-Y分级与嗅觉的相关性。结果 PD组年龄、性别、发病时间、UPDRS、H-Y分级与嗅觉阈值之间比较无明显区别。PD组的嗅觉阈值远高于正常人群对照组(P<0.01),但与阿尔茨海默病组比较并没有统计学差异(P>0.05)。结论 PD患者的嗅觉功能可以通过嗅觉定量测量有效反映,但不能作为帕金森病早期诊断的特异性指标。

Investigation of quantified olfactory function in the early diagnosis of Parkinson's disease

Objective: To investigate the olfactory function in Chinese patients with Parkinson’s disease(PD) and to explore the significance of quantified olfactory function in diagnosing PD.Methods: The threshold of olfactory detection was determined by the modified CCCRC method.There are three groups: 30 patients with Parkinson’s disease in the trial group,25 patients with Alzheimer’s disease in one of the control group and normal people in another control group.The association of threshold of olfactory detection with age,duration of disease,UPDRS score and H-Y level were analyzed using SPSS.Results: The olfactory detection threshold in PD patients was significantly higher than that in one controls,but there was no significant difference from another group(P>0.05).There was no association observed between the olfactory function and the age,duration,UPDRS score or H-Y level.Conclusion: Quantified olfactory function is a useful method to assess the PD patients’ olfactory ability.But the study can’t determine whether the olfactory dysfunction constitutes the diagnostic criteria for Parkinson disease.