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| 32P-胶体磷酸铬联合p53基因治疗恶性胸腔积液的临床研究 | |
| 引用本文： | 张长明,左书耀,闫瑞红.32P-胶体磷酸铬联合p53基因治疗恶性胸腔积液的临床研究[J].泰山医学院学报,2012,33(2):92-94. |
| 作者姓名： | 张长明 左书耀 闫瑞红 |
| 作者单位： | 1. 青岛大学医学院附属医院核医学科,山东,青岛,266021;聊城市人民医院核医学科,山东,聊城,252000 2. 青岛大学医学院附属医院核医学科,山东,青岛,266021 3. 聊城市人民医院核医学科,山东,聊城,252000 |
| 摘 要： | 目的观察32P-胶体磷酸铬联合p53基因治疗恶性胸腔积液的近期疗效及毒副作用。方法 42例确诊为单侧恶性胸腔积液的患者,随机分为实验组和对照组。实验组用重组人p53腺病毒注射液联合32P-胶体磷酸铬治疗,对照组单用32P-胶体磷酸铬。所有治疗每月一次,治疗两次后评价疗效。结果实验组总有效率(CR+PR)为81.0%,对照组总有效率(CR+PR)为47.6%。实验组与对照组比较,差异具有统计学意义(x2=5.081,P<0.05)。结论 32P-胶体磷酸铬与p53基因联合治疗可以有效地控制恶性胸腔积液。 |
| 关 键 词： | 恶性胸腔积液 重组人p53腺病毒注射液 放射性核素 32P-胶体磷酸铬 |
Clinical study of colloidal chromic phosphate 32P combined with p53 gene for the treatment of malignant pleural effusion |
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| ZHANG Chang-ming , ZUO Shu-yao , YAN Rui-hong.Clinical study of colloidal chromic phosphate 32P combined with p53 gene for the treatment of malignant pleural effusion[J].Journal of Taishan Medical College,2012,33(2):92-94. | |
| Authors: | ZHANG Chang-ming ZUO Shu-yao YAN Rui-hong |
| Institution: | 1.Dept.of Nuclear Medicine,Affiliated Hospital of Qingdao University Medical College,Qingdao 266021,China; 2.Dept.of Nuclear Medicine,Liaocheng People’s Hospital,Liaocheng 252000,China) |
| Abstract: | Objective: To evaluate the recent curative effect and side effect of colloidal chromic phosphate 32P combined with p53 gene for the treatment of malignant pleural effusion.Methods:42 patients diagnosed as single side malignant pleural effusion were randomly divided into 2 groups.The patients of experimental group were treated by recombinant adenovirus p53 injection(rAD-p53) combined with colloidal chromic phosphate 32P.The patients of the control group were treated by colloidal chromic phosphate 32P per month.The therapeutic effects were evaluated after 2 courses.Results:The total effective rate(CR+PR) was 81.0% in the experimental group and 47.6% in the control group.There was significant difference between the two groups(χ2=5.081,P<0.05).Conclusion:Colloidal chromic phosphate 32P and rAd-p53 is effective on malignant pleural effusion. |
| Keywords: | malignant pleural effusion recombinant human Ad-p53 injection radioisotopes colloidal chromic phosphate 32P |
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