| 胃食管反流病的危险因素以及相关疾病的研究概况 |
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| 引用本文： | 张玉琴,巴亚斯古楞,任建林. 胃食管反流病的危险因素以及相关疾病的研究概况[J]. 胃肠病学, 2012, 17(5): 307-310 |
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| 作者姓名： | 张玉琴 巴亚斯古楞 任建林 |
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| 作者单位： | 厦门大学附属中山医院消化内科 厦门大学消化疾病研究所 厦门市消化疾病中心 361004 |
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| 摘 要： | 胃食管反流病（GERD）是西方国家比较常见的疾病，近年亚洲国家的发病率呈上升趋势，其发病机制复杂。与GERD发生相关的分子机制主要包括IL-1β、IL-8、E-钙黏蛋白、PAR-2、COL3A1等，遗传因素、肥胖、生活方式、精神心理因素、药物、人口因素、食管裂孔疝等可能是GERD的危险因素。此外，GERD可导致多种食管外相关疾病和食管腺癌。本文就此作一综述。
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| 关 键 词： | 胃食管反流 危险因素 食管外相关疾病 |
Risk Factors and Related Diseases of Gastroesophageal Reflux Disease |
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| ZHANG Yuqin , Bayasiguleng , REN Jianlin.. Risk Factors and Related Diseases of Gastroesophageal Reflux Disease[J]. Chinese Journal of Gastroenterology, 2012, 17(5): 307-310 |
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| Authors: | ZHANG Yuqin Bayasiguleng REN Jianlin. |
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| Affiliation: | .Department of Gastroenterology,Zhongshan Hospital of Xiamen University,Institute of Digestive Disease,Xiamen University,Xiamen Digestive Disease Center,Xiamen,Fujian Province(361004) |
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| Abstract: | Gastroesophageal reflux disease(GERD) is common in Western countries,and the incidence of GERD is increasing in Asian in recent years,the pathogenesis of GERD is complicated.The molecular mechanism of GERD includes IL-1β,IL-8,E-cadherin,PAR-2,COL3A1,etc.Genetic factor,obesity,life style,psychological factor,drugs,demography and esophageal hiatal hernia can be considered as risk factors for GERD.Moreover,GERD can cause extraesophageal related diseases and esophageal adenocarcinoma.This article reviewed the risk factors and related diseases of GERD. |
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| Keywords: | Gastroesophageal Reflux Risk Factors Extraesophageal Related Diseases |
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