| 尿激酶与蝮蛇抗栓酶—3局部溶栓疗效动物实验对照研究 |
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| 引用本文： | 许成平,汪云祥,周良,吴祖舜,王小冬. 尿激酶与蝮蛇抗栓酶—3局部溶栓疗效动物实验对照研究[J]. 实用放射学杂志, 1996, 0(2) |
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| 作者姓名： | 许成平 汪云祥 周良 吴祖舜 王小冬 |
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| 作者单位： | 南京医科大学第二附属医院放射科!210011(许成平，汪云祥，周良)，南京医科大学第二附属医院神经内科!210011(吴祖舜，王小冬) |
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| 摘 要： | 从成年犬股动脉内抽取动脉血.在常温下静置2～4h凝固后切成模拟自体血栓.采用Seldinger’s法将导管经犬股动脉插入其推动脉或颈总动脉.将自体血栓经导管推注入脑动脉.点片证实脑动脉分支被栓后1/2h至8h末.再经导管分别灌注蝮蛇抗栓酶—3(Svate—3)或尿激酶(UK)后.分次观察溶栓效果.证实Svate—3能溶解6h以内的栓子.而UK只能溶解5h以内的栓子.
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| 关 键 词： | 蝮蛇抗栓酶-3 尿激酶 脑动脉栓塞 溶栓 |
Investigation on Throbolytic Therapy with Urokinase or Svate-3 in Cerebral Arterial Thrombosis of Dogs |
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| Xu Chengping Wang Yunxiang Wu Zushun et al.. Investigation on Throbolytic Therapy with Urokinase or Svate-3 in Cerebral Arterial Thrombosis of Dogs[J]. Journal of Practical Radiology, 1996, 0(2) |
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| Authors: | Xu Chengping Wang Yunxiang Wu Zushun et al. |
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| Affiliation: | Xu Chengping Wang Yunxiang Wu Zushun et al. |
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| Abstract: | Eighteen dogs were successfully treated with interventional technique. Autoemboli were injected into carotid artery or vertebral artery to induce ceredral arterial obstruction. Svate-3 at a dose of 0. 05u/kg and urokinase(UK) at a dose of 4000U/kg were administered interarteriously to dissolve cerebral arterial emboli. Selective catheter arteriography were performed before or after svate-3 or UK administration. In this study Svate-3 might cause reperfusion within six hours (maximum) and UK develop reperfusion within five hours(maximum) respectively. The mechanism and evaluation of the interventional technique with thrombolytic therapy were discussed. HT] |
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| Keywords: | Svate-3 Urokinase Cerebral embolism Thrombolytic therapy |
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