帕罗西汀治疗原发性失眠症

目的 :探讨帕罗西汀对原发性失眠症的疗效和副作用。方法 :帕罗西汀组 2 5例 ,男性 1 0例 ,女性 1 5例 ,年龄 (5 5±s1 2 )a,予帕罗西汀 1 0～ 3 0mg·d-1,po;阿普唑仑组 2 5例 ,男性 1 1例 ,女性 1 4例 ,年龄 (5 7± 1 3 )a,予阿普唑仑 0 .4～ 0 .8mg·d-1,po;安慰剂组 2 5例 ,男性 9例 ,女性 1 6例 ,年龄 (5 6± 1 2 )a,给予安慰剂 2片 ,po,qd。疗程均为 8wk ,治疗前及治疗wk 2 ,4,8末采用PSQI,TESS评定疗效及副作用。结果 :帕罗西汀组显效率 88% ,阿普唑仑组显效率 5 6% ,经Ridit分析 ,P <0 .0 1。帕罗西汀组常见副作用有口干、便秘、恶心等 ,不影响治疗。结论 :帕罗西汀治疗原发性失眠症疗效确切 ,副作用轻微

Paroxetine in treatment of primary insomnia

AIM: To investigate the clinical effect and adverse reactions of paroxetine in the treatment of primary insomnia. METHODS: Seventy five patients who met Chinese classification and diagnostic criteria of mental disorders, 2nd Rev Ed, (CCMD 2 R) criteria for primary insomnia were randomly divided into three groups. Paroxetine group of twenty five patients (M 10,F 15; age 55 a± s 12 a) was treated with paroxetine 10 30 mg·d -1 , po , qd or bid. Alprazolam group of twenty five patients (M 11,F 14; age 57 a±13 a) was treated with alprazolam 0.4 0.8 mg·d -1 , po , qn. Placebo group of twenty five patients (M 9,F 16; age 56 a±12 a) was treated with placebo two tablets, po , qn, for 8 wk. Effects and adverse reactions were evaluated with Pittsburgh sleep quality index(PSQI) and treatment emergent symptoms scale(TESS), before and after the wk 2,4,8 of treatment. RESULTS: The excellent effective rates of paroxetine group and alprazolam group were 88 % and 56 %, respectively ( P <0.01). The adverse reactions of paroxetine group were dry mouth, conspation, nausea, but those were less than that of alprazolam. CONCLUSION: The study suggests that paroxetine is an effective drug for the treatment of primary insomnia, and adverse reaction is mild.