Excitatory effects of ACTH on noradrenergic neurons of the locus coeruleus in the rat |
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| Authors: | H.R. Olpe R.S.G. Jones |
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| Affiliation: | Department of Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, U.S.A. |
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| Abstract: | Responses of presumed noradrenaline-containing neurons in locus coeruleus (LC) to iontophoretically applied ACTH were determined. The full sequence ACTH1-39 and the partial sequence ACTH1-24 were excitatory on the majority of neurons tested. The partial sequence ACTH27-39 was without effect on most neurons. The presence of ACTH-containing fibers in LC together with the present results may suggest a controlling influence of the peptide on the noradrenaline system. |
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| Keywords: | ACTH locus coeruleus iontophoresis noradrenaline |
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