Primary polypeptide hormones and mucin-producing malignant carcinoid of the larynx |
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| Authors: | F Cefis M Cattaneo P M Carnevale Ricci B Frigerio L Usellini C Capella |
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| Affiliation: | a Departments of Pathology and Otorhinolaryngology, Istituti Clinici di Perfezionamento, Milano, Italyb Research Center for Diagnostic Histopathology, Varese Regional Hospital and University of Pauin,c Research Center for Diagnostic Histopathology and Institute of Pathologic Anatomy, University of Pavia, Varese, Italy |
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| Abstract: | A case of primary malignant laryngeal carcinoid with dual endocrine and mucous differentiation i s reported. Histologically the tumor showed a characteristic organoid pattern and exhibited Alcian-blue, periodic acidschiff, and Grimelius silver positivity. By the immunoperoxidase technique cal citoni n, ACTH, and or-hCG subunit were demonstrated in the tumor cells. ELectron microscopy revealed two different types of endocrinelike cells: mucous cells and occasional cells containing both endocrinelike granules and mucin droplets. Diagnostic morphologic criteria of this rare tumor entity are discussed and reference t o biologic behavior and possible h istogenesis is made. |
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| Keywords: | malignant laryngeal carcinoid polypep tide hormones secretory granules electron microscopy immunoperoxidase |
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