肝细胞肝癌病人围手术期血清IL-10的变化及意义

目的 检测肝细胞肝癌（ＨＣＣ）病人围手术期血清ＩＬ－１０浓度并探讨其意义。方法 用ＥＬＩＳＡ检测法测定了３０例ＨＣＣ病人术前、术后血清ＩＬ－１０浓度，以３０例健康人为对照。结果 ＨＣＣ病人术前、术后血清ＩＬ－１０浓度均高于健康人，术前血清ＩＬ－１０浓度高于术后。肿瘤直径〉５ｃｍ和低分化的病人血清ＩＬ－１０浓度高于肿瘤直径〈５ｃｍ和高分化者（Ｐ〈０．０１）。结论 ＨＣＣ细胞可能产生ＩＬ－１０，ＩＬ－１０可能参与ＨＣＣ的免疫调节，ＩＬ－１０可能是一个可反映ＨＣＣ分化程度、估计预后及预测复发的指标。

Changes of serum IL-10 in perioperative period in patients with hepatocellular carcinoma and its significance

Objective To determine the changes of serum IL 10 level in perioperative period in patients with hepatocellular carcinoma (HCC) and discuss its significance. Methods The serum IL 10 level was determined with ELISA in 30 patients with HCC and 30 healthy volunteers. Results The serum IL 10 level was significantly higher in the perioperative period in patients with HCC than in the healthy volunteers. In the patients with HCC, the level was higher before than after the operation. Meanwhile, it was markedly higher in patients with poorly differentiated tumor or the tumor with a diameter over 5 cm than in those with well differentiated tumor or the tumor with a diameter less than 5 cm (P<0 01). Conclusion HCC cells might produce IL 10 that may participate in immune response of HCC. Furthermore, IL 10 might be a factor that can reflect the differentiation grade, assess the prognosis and predict recurrence of HCC.