| 葫芦烷型降三萜类化合物的研究进展 |
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| 引用本文： | 霍晓爽,王钧篪,斯建勇.葫芦烷型降三萜类化合物的研究进展[J].中草药,2022,53(5):1558-1569. |
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| 作者姓名： | 霍晓爽 王钧篪 斯建勇 |
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| 作者单位： | 中国医学科学院 北京协和医学院药用植物研究所 中草药物质基础与资源利用教育部重点实验室，北京 100193 |
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| 基金项目： | 中国医学科学院创新工程项目（2017-12M-1-013） |
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| 摘 要： | 葫芦烷型降三萜类化合物是一类结构新颖的化合物,是在葫芦烷型三萜的30个碳骨架的基础上减少1个或几个碳所得.按其缺少碳原子的位置可分为2-降(a)、3-降(b)、19-降(c)、27-降(d)、29-降(e)、19,29-降(f)、25,26,27-降(g)、24,25,26,27-降(h)、23,24,25,26,27...
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| 关 键 词： | 葫芦烷型降三萜 抗肿瘤 抗炎 降血糖 抗氧化 |
| 收稿时间： | 2021/6/23 0:00:00 |
Research progress on nor-cucurbitacin triterpenes |
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| HUO Xiao-shuang,WANG Jun-chi,SI Jian-yong.Research progress on nor-cucurbitacin triterpenes[J].Chinese Traditional and Herbal Drugs,2022,53(5):1558-1569. |
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| Authors: | HUO Xiao-shuang WANG Jun-chi SI Jian-yong |
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| Institution: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China |
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| Abstract: | Nor-cucurbitacin triterpenes are a class of compounds with novel structures, which are formed by the reduction of one or several carbons on the 30 carbons skeleton of cucurbitacin-type triterpenoids. According to the position of vacant carbon atom, they could be divided into twelve types, including 2-nor (a), 3-nor (b),19-nor (c), 27-nor (d), 29-nor (e), 19,29-nor (f), 25,26,27-nor (g), 24,25,26,27-nor (h), 23,24,25,26,27-nor (i), 22,23,24,25,26,27-nor (j), 22,23,24,25,26,27,29-nor (k) and 20,21,22,23,24,25,26,27-nor (l). Moreover, nor-cucurbitacin triterpenes have various pharmacological effects, such as antitumor, anti-inflammation, antidiabetics, and anti-oxidant, etc. Plant distribution, chemical structural characteristics and pharmacological activities of nor-cucurbitacin triterpenes were systematically summarized in this paper, in order to provide a reference for further development and rational utilization of these compounds. |
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| Keywords: | nor-cucurbitacin triterpenes antitumor anti-inflammation antidiabetics anti-oxidant |
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