| 基于化学成分、药理作用和网络药理学的余甘子质量标志物(Q-Marker)预测分析 |
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| 引用本文： | 陈静梅,郝二伟,杜正彩,李思维,王星圆,侯小涛,邓家刚. 基于化学成分、药理作用和网络药理学的余甘子质量标志物(Q-Marker)预测分析[J]. 中草药, 2022, 53(5): 1570-1586 |
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| 作者姓名： | 陈静梅 郝二伟 杜正彩 李思维 王星圆 侯小涛 邓家刚 |
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| 作者单位： | 广西中医药大学药学院，广西 南宁 530200;广西中药药效研究重点实验室，广西 南宁 530200;广西农作物废弃物功能成分研究协同创新中心，广西 南宁 530200;广西中药药效研究重点实验室，广西 南宁 530200;广西农作物废弃物功能成分研究协同创新中心，广西 南宁 530200;广西中医药大学 广西中医药科学实验中心，广西 南宁 530200 |
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| 基金项目： | 2017年广西中药药效研究重点实验室（17-259-20）；广西中医药大学2020年研究生教育创新计划项目（YCSZ2020008）；广西高等学校高水平创新团队及卓越学者计划项目（2019-52） |
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| 摘 要： | 余甘子为大戟科植物余甘子Phyllanthus emblica的干燥成熟果实.对余甘子化学成分及主要药理作用进行综合分析,基于中药质量标志物(quality marker,Q-Marker)理论,对余甘子从传统药性、药效、药效物质基础和化学成分可测性的角度进行Q-Marker初步预测.基于文献整合及数据分析对余甘子Q-...
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| 关 键 词： | 余甘子 质量标志物 酚酸类 黄酮类 木犀草素 槲皮素 山柰酚 (-)-表没食子儿茶素-3-没食子酸酯 |
| 收稿时间： | 2021-07-09 |
Predictive analysis on quality marker of Phyllanthus emblica based on chemical composition, pharmacological effects and network pharmacology |
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| CHEN Jing-mei,HAO Er-wei,DU Zheng-cai,LI Si-wei,WANG Xing-yuan,HOU Xiao-tao,DENG Jia-gang. Predictive analysis on quality marker of Phyllanthus emblica based on chemical composition, pharmacological effects and network pharmacology[J]. Chinese Traditional and Herbal Drugs, 2022, 53(5): 1570-1586 |
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| Authors: | CHEN Jing-mei HAO Er-wei DU Zheng-cai LI Si-wei WANG Xing-yuan HOU Xiao-tao DENG Jia-gang |
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| Affiliation: | School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China;Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning 530200, China;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China;Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning 530200, China;Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China |
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| Abstract: | Yuganzi (Phyllanthi Fructus) is the dry mature fruit of Phyllanthus emblica in Euphorbiaceae. Chemical composition and main pharmacological activities of P. emblica were summarized in this paper, based on quality marker (Q-Marker) theory of traditional Chinese medicine, Q-Marker of P. emblica was predicted and analyzed from the perspective of traditional medicinal property and efficacy, chemical composition effectiveness and measurability. Based on literature integration and data analysis, Q-Marker source range of P. emblica was screened, and the effectiveness of components of P. emblica was further confirmed through network pharmacology. Phenolic acids and luteolin, quercetin, kaempferol, and (−)-epigallocatechin-3-gallate in flavonoids can be used as the main Q-Markers of P. emblica, in order to provide reference for the whole quality control of P. emblica. |
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| Keywords: | Phyllanthus emblica L. quality marker phenolic acids flavonoids luteolin quercetin kaempferol (− )-epigallocatechin-3-gallate |
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