阿托伐他汀与瑞舒伐他汀对阵发性心房颤动患者射频消融术后复发率及心房电重构的影响比较

目的 比较阿托伐他汀与瑞舒伐他汀对阵发性心房颤动患者射频消融术后复发率及心房电重构的影响.方法 选择2019年1月至2020年6月于郑州大学附属洛阳中心医院心内科接受射频消融的阵发性房颤患者120例,采用随机数字表法分为阿托伐他汀组、瑞舒伐他汀组以及无他汀治疗组,每组40例.三组术后均接受口服奥美拉唑治疗1个月,华法林...

Comparison of the effects of atorvastatin and rosuvastatin on recurrence rate and atrial electrical remodeling after radiofrequency ablation in patients with paroxysmal atrial fibrillation

Objective To compare the effects of atorvastatin and rosuvastatin on recurrence rate and atrial electrical remodeling after radiofrequency ablation in patients with paroxysmal atrial fibrillation.Methods One hundred and twenty patients with paroxysmal atrial fibrillation who underwent radiofrequency ablation in Department of Cardiology,Luoyang Central Hospital Affiliated to Zhengzhou University from January 2019 to June 2020 were selected and divided into the atorvastatin group,the rosuvastatin group and the non-statin treatment group by random number table method,with 40 cases in each group.All the three groups received oral omeprazole treatment for 1 month,warfarin or rivaroxaban treatment for at least 2 months,and amiodarone treatment for 3 months.On this basis,the atorvastatin group received atorvastatin treatment,20 mg each time,once a day,for 3 months,and the rosuvastatin group received rosuvastatin treatment,10 mg each time,once a day,for 3 months.The non-statin treatment group did not receive any statin.The recurrence rate of atrial fibrillation,P-wave dispersion of electrocardiogram and low-density lipoprotein level were compared among the three groups 6 months after operation.Results Within 6 months after operation,atrial fibrillation recurred in 8 cases(20.00%)in the atorvastatin group,10 cases(25.00%)in the rosuvastatin group,and 12 cases(30.00%)in the non-statin treatment group.There was no significant difference in the recurrence rate of atrial fibrillation among the three groups(χ²=1.067,P=0.587).Compared with that before operation,the P-wave dispersion of electrocardiogram in the atorvastatin group reduced significantly 6 months after operation(P<0.05).However,compared with that before operation,the P-wave dispersion of electrocardiogram in the rosuvastatin group and the non-statin treatment group was not significantly different 6 months after the operation(P>0.05).Compared with those before operation,the levels of low-density lipoprotein in the atorvastatin group and the resuvastatin group reduced significantly 6 months after operation(P<0.05).However,compared with that before operation,the level of low-desity lipoprotein in the non-statin treatment group was not significantly different 6 months after the operation(P<0.05).Conclusion There is no significant difference between atorvastatin and rosuvastatin in the short-term recurrence rate of patients with paroxysmal atrial fibrillation after radiofrequency ablation,but the P-wave dispersion of electrocardiogram of the atorvastatin group decreases more significantly,suggesting that lipophilic atorvastatin is more conducive to improving atrial electrical remodeling.