| 分心木中2个新的脂肪酸酯 |
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| 引用本文： | 谭金燕,李建丽,苏琪辉,李慧,程艳刚,乔元彪,李青山,王颖莉. 分心木中2个新的脂肪酸酯[J]. 中草药, 2022, 53(5): 1360-1364 |
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| 作者姓名： | 谭金燕 李建丽 苏琪辉 李慧 程艳刚 乔元彪 李青山 王颖莉 |
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| 作者单位： | 山西中医药大学，基于炎性反应的重大疾病创新药物山西省重点实验室，山西 晋中 030619;山西中医药大学，山西省现代中药工程实验室，山西 晋中 030619 |
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| 基金项目： | 山西省卫生健康委科研项目（2020094）；基于炎性反应的重大疾病创新药物山西省重点实验室开放基金资助项目（2021sxcxyw10）；中央引导地方科技发展资金项目（YDZX20201400001518） |
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| 摘 要： | 目的 研究分心木Diaphragma Juglandis Fructus的化学成分.方法 采用正相硅胶、反相ODS、中压制备液相色谱和制备型高效液相色谱等多种色谱技术和手段进行分离和纯化,通过1D和2D-NMR、HR-ESI-MS等谱学数据分析鉴定化合物结构.结果 从分心木中共分离得到5个脂肪酸类成分,分别鉴定为胡桃酸...
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| 关 键 词： | 分心木 胡桃 脂肪酸 十八烷酸 胡桃酸酯A 胡桃酸酯B 9S 12S 13S-三羟基十八烷-10E 15Z-二烯酸 |
| 收稿时间： | 2022-01-05 |
Two new fatty acid esters from Diaphragma Juglandis Fructus |
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| TAN Jin-yan,LI Jian-li,SU Qi-hui,LI Hui,CHENG Yan-gang,QIAO Yuan-biao,LI Qing-shan,WANG Ying-li. Two new fatty acid esters from Diaphragma Juglandis Fructus[J]. Chinese Traditional and Herbal Drugs, 2022, 53(5): 1360-1364 |
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| Authors: | TAN Jin-yan LI Jian-li SU Qi-hui LI Hui CHENG Yan-gang QIAO Yuan-biao LI Qing-shan WANG Ying-li |
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| Affiliation: | Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Jinzhong 030619, China;Shanxi Modern Chinese Medicine Engineering Laboratory, Shanxi University of Chinese Medicine, Jinzhong 030619, China |
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| Abstract: | Objective To study the chemical constituents from Diaphragma juglandis Fructus. Methods The chemical constitutes were isolated and purified by silica gel, ODS, preparative MPLC and preparative HPLC. Their structures were elucidated based on 1D-NMR, 2D-NMR, and HR-ESI-MS. Results Five fatty acids compounds were isolated and identified from Diaphragma juglandis Fructus. The structures of 1 and 2 were established and named juglans acid ester A (1) and juglans acid ester B (2), respectively. The other compounds were identified as pinellic acid (3), (Z)-11R,12S,13S-trihydroxy-9-octadecenoate (4), and 9S,12S,13S-trihydroxy-octadeca-10E,15Z-dienoic acid (5). Conclusions Compounds 1 and 2 are new fatty acid esters. Compounds 3-5 are isolated from Juglans regia for the first time. |
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| Keywords: | Diaphragma Juglandis Fructus Juglans regia L. fatty acids octadecanoic acid juglans acid ester A juglans acid ester B 9S,12S,13S- trihydroxy-octadeca-10E,15Z-dienoic acid |
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