青石棉、苯并(a)芘气管染尘大鼠血中SOD和LPO变化的研究

为了观察青石棉、苯并（ａ）芘染尘大鼠血中超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）的变化，以探讨其致癌机制，用气管内染尘法，在染尘后９０，１８０，２７０，３６０和５４０天时观察大鼠ＳＯＤ、ＬＰＯ及ＳＯＤ／ＬＰＯ比值的变化，采用方差分析处理数据。结果提示，青石棉、苯并（ａ）芘可致ＳＯＤ活性降低、ＬＰＯ含量升高、ＳＯＤ／ＬＰＯ比值降低的趋势。表明体内抗氧化和脂嵵使趸胶馐У鳌

Studies on the plasmic level of SOD and LPO in the processes of lung cancer induced by crocidolite and benzo (a) pyrene in rats

To explore the mechanism of carcinogenicity of crocidolite and benzo (a) pyrene , wis- tar rats were divided into 4 groups at random for exposure , that were Cro. group. B (a ) p group , Cro. plus B(a)p group and control group. Samples of blood were collected in 90 , l80 , 270 , 360 and 540 days after the third time of intratracheal injection , and the SOD activity and LPO level were measured , the statistics method was F test. The results indicated the Cro. or B(a)p could de- crease the activity of SOD and increase the level of LPO , that suggesting the imbalance of antioxi- dation and oxidation by Cro. B(a)p in organisms.