Metabolic and hormonal blood flow modeling in patients with coronary heart disease: In vitro and clinical study |
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| Authors: | Lidia I Malinova Georgy V Simonenko Tatyana P Denisova Valery V Tuchin |
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| Institution: | aSaratov Scientific Research Institute of Cardiology, Chernyshevskogo Street 141, Saratov, 410028, Russia;bInstitute of Optics and Biophotonics, Saratov State University, 83 Astrakhanskaya Street, Saratov, 410012, Russia;cGerontology and Geriatrics Department, Saratov State Medical University, Bolshaya Kazachia Street 112, Saratov, 410012, Russia |
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| Abstract: | The blood flow pattern investigations are of great importance in coronary blood flow destabilization pathogenesis understanding, and consequently in acute coronary event (ACE) risk stratification in patients with coronary heart disease. The aim of the study was to research the principal hormonal and metabolic blood flow regulative aspects and its structure in patients with ischemic heart disease and the contribution to cumulative ACE risk.A total of 182 patients with stable angina pectoris were included in the prospective study (2000–2006). Complex clinical examination, biochemical tests and blood tests were performed. Whole-blood (WB) viscosity, erythrocyte aggregation and deformation ability, WB suspension stability, and initial erythrocytes disaggregation parameter were studied. Dynamic characteristics of blood flow were obtained in the experiment.Received results allow marking the principle components of blood flow pattern with proven high prognostic value of ACE in patients with ischemic heart disease. ACE risk stratification program was developed. |
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| Keywords: | Blood flow structure Coronary heart disease Acute coronary event risk stratificationSchlü sselwö rter: Blutflussverhalten Koronare Herzkrankheit Akutes koronares Ereignis Programm zur Risiko-VorhersagePalabras clave: Patró n de flujo sanguí neo Enfermedad cardí aca coronaria Estratificació n del riesgo de sí ndrome coronario agudo |
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