Clinical and medial temporal features in a family with mood disorders |
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| Authors: | Marina Boccardi Monica Almici Lorena Bresciani Anna Caroli Matteo Bonetti Sergio Monchieri Massimo Gennarelli Giovanni B. Frisoni |
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| Affiliation: | 1. LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine – IRCCS San Giovanni di Dio-FBF, Brescia, Italy;2. Medical Imaging Unit, Biomedical Engineering Department, Mario Negri Institute for Pharmacological Research, Bergamo, Italy;3. Service of Neuroradiology, Istituto Clinico Città di Brescia, Brescia, Italy;4. Mental Disability Service – IRCCS San Giovanni di Dio-FBF, Brescia, Italy;5. Genetics Unit - IRCCS San Giovanni di Dio-FBF, Brescia, Italy;6. Psychogeriatric Ward - IRCCS San Giovanni di Dio-FBF, Brescia, Italy;g AFaR Associazione Fatebenefratelli per la Ricerca, Rome, Italy |
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| Abstract: | It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D magnetic resonance imaging of five affected family members, 10 non-affected relatives, and 15 unrelated matched controls. Affected and non-affected relatives were characterized by larger left amygdalae (18%, p = 0.030), smaller right hippocampus (up to 18%, p < 0.0005), and reduced hippocampal asymmetry (p < 0.001) than controls. Abnormal, albeit non significant, positive correlations of MTL volumes with age were observed, with the exception of smaller volume of the left hippocampus with advancing age (r = −0.76) in the affected relatives. These data add to the evidence that abnormal medial temporal structures may constitute an endophenotype for affective disorders. |
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| Keywords: | Familial mood disorder Hippocampus Amygdala MRI Morphometry Endophenotype |
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