Moscatilin,a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo |
| |
| Authors: | An-Chi Tsai Shiow-Lin Pan Cho-Hwa Liao Jih-Hwa Guh Shih-Wei Wang Hui-Lung Sun Yi-Nan Liu Chien-Chih Chen Chien-Chang Shen Ya-Ling Chang Che-Ming Teng |
| |
| Affiliation: | 1. Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan;2. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan;3. National Research Institute of Chinese Medicine, Taipei, Taiwan;4. Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan |
| |
| Abstract: | Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy. |
| |
| Keywords: | Moscatilin VEGF bFGF Endothelial cells Angiogenesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
