miR-126 functions as a tumour suppressor in human gastric cancer |
| |
Authors: | Runhua Feng Xuehua Chen Yingyan Yu Liping Su Beiqin Yu Jianfang Li Qu Cai Min Yan Bingya Liu Zhenggang Zhu |
| |
Affiliation: | 1. Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People’s Republic of China;2. Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People’s Republic of China;3. Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People’s Republic of China |
| |
Abstract: | MicroRNAs have emerged as important gene regulators and are recognised as key players in carcinogenesis. In the present study, we show that miR-126 was significantly down-regulated in gastric cancer tissues compared with matched normal tissues and was associated with clinicopathological features, including tumour size, lymph node metastasis, local invasion and tumour-node-metastasis (TNM) stage. Ectopic expression of miR-126 in SGC-7901 gastric cancer cells potently inhibited cell growth by inducing cell cycle arrest in G0/G1 phase, migration and invasion in vitro as well as tumorigenicity and metastasis in vivo. Mechanistically, we identified the adaptor protein Crk as a target of miR-126. Taken together, our results suggest that miR-126 may function as a tumour suppressor in gastric cancer, with Crk as a direct target. |
| |
Keywords: | MicroRNA Gastric cancer Proliferation Invasion Crk |
本文献已被 ScienceDirect 等数据库收录! |
|