Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro |
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| Authors: | Ching Tung Lum Xiong Liu Raymond Wai-Yin Sun Xiang-Ping Li Ying Peng Ming-Liang He Hsiang Fu Kung Chi-Ming Che Marie C.M. Lin |
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| Affiliation: | 1. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;2. Department of Otolaryngology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China;3. Department of Neurology, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China;4. Center for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong, China;5. The State Key Laboratory in Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, China |
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| Abstract: | A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. |
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| Keywords: | Gold(III) porphyrin 1a Nasopharyngeal carcinoma (NPC) Metastasis Cell migration Invasion |
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