MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells |
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| Authors: | Gang Li Zhengrong Wu Ying Peng Xiong Liu Juan Lu Lu Wang Qiuhui Pan Min-Liang He Xiang-Ping Li |
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| Affiliation: | 1. Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China;3. Department of Neurology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China;4. Medical Research Center, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China;5. Stanley Ho Center for Emerging Infectious Diseases, School of Public Health and Primary Care, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China |
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| Abstract: | MicroRNA-10b (miR-10b) has been reported to facilitate the metastasis of breast cancer. However, little is known about the role of miR-10b in the metastasis of nasopharyngeal carcinoma (NPC). Here, we show that high levels of miR-10b expression in Epstein-Barr virus (EBV)-positive latent membrane protein-1 (LMP1)-expressing NPC cells, and its expression is down-regulated by silencing LMP1 or Twist. Induction of miR-10b over-expression in LMP1-silent C666-1 cells promoted significant wound healing and transmembrane invasiveness in vitro. More importantly, miR-10b over-expression promoted the metastasis of NPC and accelerated the death of tumor-bearing nude mice. These findings strongly suggest that miR-10b positively regulates the metastasis of NPC. |
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| Keywords: | miR-10b Latent membrane protein-1 Twist Nasopharyngeal carcinoma Metastasis |
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