The BH3-mimetic GX15-070 induces autophagy,potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells |
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| Authors: | Jingxuan Pan Chao Cheng Srdan Verstovsek Qi Chen Yanli Jin Qi Cao |
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| Affiliation: | 1. Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China;2. Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;3. Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA |
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| Abstract: | Despite improvements in both surgical techniques and radio- and chemo-therapy regimens, the prognosis of esophageal cancer is poor. In pursuit of novel effective strategy, this study examined the effect of the BH3-mimetic GX15-070 on esophageal carcinoma cells. We discovered that GX15-070 inhibited the growth of esophageal cancer cells. There was synergism between GX15-070 and carboplatin or 5-fluorouracil. GX15-070 induced autophagy in esophagus cancer cell line EC9706 and osteosarcoma cancer cell line U2OS. 3-methyladenine and chloroquine, inhibitors of autophagy with distinct mechanisms, potentiated the cytotoxicity of GX15-070. In conclusion, GX15-070 inhibits growth of esophageal cancer cells. |
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| Keywords: | Esophageal cancer Targeted therapy Bcl-2 inhibitor Autophagy |
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