Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death |
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| Authors: | Vanesa Martín Guillermo García-Santos Jezabel Rodriguez-Blanco Sara Casado-Zapico Ana Sanchez-Sanchez Isaac Antolín Maria Medina Carmen Rodriguez |
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| Institution: | 1. Departamento de Morfología y Biología Celular, Spain;2. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Spain;3. Departamento de Cirugia, Area de Fisioterapia, Facultad de Medicina de la Universidad de Oviedo, Spain;4. Servicio de Rehabilitacion del Hospital de Jove, Gijon Principado de Asturias, Spain |
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| Abstract: | Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found that melatonin effectively increase cell sensitivity to TRAIL-induced cell apoptosis in A172 and U87 human glioma cells. The effect seems to be related to a modulation of PKC activity which in turns decreases Akt activation leading to an increase in death receptor 5 (DR5) levels and a decrease in the antiapoptotic proteins survivin and bcl-2 levels. |
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| Keywords: | Melatonin Glioma TRAIL Apoptosis Death receptors |
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