| 微囊化异体坐骨神经组织细胞移植对大鼠脊髓损伤后c-fos表达的影响 |
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| 引用本文： | 曾文泓,刘德明.微囊化异体坐骨神经组织细胞移植对大鼠脊髓损伤后c-fos表达的影响[J].四川解剖学杂志,2009,17(1):27-29. |
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| 作者姓名： | 曾文泓 刘德明 |
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| 作者单位： | 南昌大学医学院人体解剖教研室,江西南昌,330006 |
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| 摘 要： | 目的探讨微囊化异体坐骨神经组织细胞移植对大鼠脊髓损伤后c-fos表达的影响。方法95只SD大鼠随机分为4组，A组为微囊化坐骨神经细胞移植组（30只）；B组为坐骨神经细胞移植组（30只）；C组为单纯损伤对照组（30只），仅用明胶海绵填塞SCI腔隙；D组为正常对照组（5只），仅打开椎管，暴露脊髓不作移植。用免疫组织化学的方法观察移植术后6h-14d脊髓中c-fos基因的表达情况。结果脊髓半横断损伤后对照组脊髓中6h、12h内表达c-fos阳性的神经元数增多，平均光密度值升高，至24h又明显增强。而A组脊髓后角内的c-fos表达明显低于同时间点的B组和C组（P〈0．05）。结论微囊化坐骨细胞移植可能降低c-fos的表达，并在一定程度上减轻脊髓的继发性损伤。
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| 关 键 词： | 微囊 脊髓损伤 c-fos基因 继发性损伤 |
Effects of Tansplanting Mcrocapsulated Allogenic Sciatic Neuron on Expression of c-fos in Spinal Cord after Injury of Rats |
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| Zeng Wen-hong,Liu De-ming.Effects of Tansplanting Mcrocapsulated Allogenic Sciatic Neuron on Expression of c-fos in Spinal Cord after Injury of Rats[J].Sichuan Journal of Anatomy,2009,17(1):27-29. |
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| Authors: | Zeng Wen-hong Liu De-ming |
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| Institution: | Department of Anatomy;Medical College;Nanchang University;Nanchang 330006 |
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| Abstract: | Objective To study the effects of tansplanting mcrocapsulated allogenic sciatic neuron on expression of c-fos in spinal cord after injury of rats.Methods 95 rats were randomized into 4 groups,A group(30 rats) were implanted mcrocapsulated allogenic sciatic neuron,B group(30 rats) were implanted sciatic neuron,C group(30 rats) were packed gelatin sponge as simple injury group and another 5 rats were used as normal control group,which implanted nothing after the hemisected operation.The expression of c-fos in... |
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| Keywords: | Microcapsules Spine cord injury C-fos gene Secondary lesion |
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